Lee is new. Contraceptive news. News after special events
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Novinet refers to oral monophasic contraceptives and is designed to prevent unwanted pregnancy in women. It contains synthetic polar hormones, the action of which is to inhibit the maturation of the egg and prevent the movement of spermatozoa in the cervical canal.
Properties and components of the drug
The release form of Novinet are round yellow film-coated tablets. Each tablet is engraved with RG. Tablets are on blisters of 21 pieces. Each carton contains 1 or 3 blisters. The drug is produced by the Hungarian pharmaceutical company Gedeon Richter.
The shelf life of the drug is 3 years at a temperature not exceeding 30 degrees.
Among the analogues of Novinet, the following means are considered the most popular: Mercilon, Regulon and Marvelon.
Chemical composition of Novinet
The active components of this drug are desogestrel and ethinylextradiol. And also in the composition of Novinet contains the following additional substances:
- Stearic acid.
- colloidal dioxide.
- magnesium stearate.
- lactose monohydrate.
- vegetable starch.
The shell contains propylene glycol and macrogol. The yellow color of the tablet is given by the quinoline dye E 104.
How the contraceptive works
The active components of the drug are synthetic hormones which are more active than natural sex hormones. Due to this action, the process of ovulation is suppressed. Novinet has a high degree of absorption. The active substances are evenly distributed in the tissues of the internal organs and, after 24 hours, are excreted with the help of urine and bile. Under the action of this agent, mucus thickens in the cervical canal, which, in turn, prevents the passage of spermatozoa.
Novinet has a number of advantages compared to other contraceptives:
- Reliably protects against unwanted pregnancy.
- Under the influence of this drug, there is a reduction in blood loss during menstruation.
- In women, the cycle stabilizes, and menstruation passes painlessly and quickly.
- Regular intake of Novinet guarantees the absence of an ectopic pregnancy.
- Improves the condition of the skin and hair.
- This contraceptive prevents the development of tumor diseases.
The drug is indicated for oral contraception. It can be used both before the onset of the first pregnancy and after. Novinet is recommended for use in menopause, since during this period the risk of an unplanned pregnancy is very high.
How to use this remedy
Tablets are taken daily at certain times of the day. After they finish one blister, take a seven-day break and continue taking it with a new package.
You should start using this remedy from the 1st or 2nd day of the menstrual cycle.
The transition from one oral contraceptive to another occurs as follows: wait for the onset of menstruation, skip 7 days and start taking Novinet tablets. If the replacement of the drug occurred between cycles, then Novinet is used the next day after the previous drug has ended.
After childbirth, Novinet is used on the 28th day, and after an abortion, the first contraceptive pill is drunk on the same day and the course is continued from the very beginning.
If for any reason one tablet was missed, then it can be drunk along with the next, but only with a time gap of 3-4 hours.
Contraindications for use
This drug has many contraindications and side effects. Among them are the following:
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Side effects
Often, side effects occur during the use of birth control pills. These may be the following symptoms:
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To avoid such effects, before using Novinet, you should take blood tests for the state of hormones. It is not recommended to use any hormonal contraceptives without first consulting a doctor.
Reviews about taking the drug
Before Novinet, I used Jess. My gynecologist advised me to switch to a new drug after I turned to him with complaints about breast swelling and scanty periods. For some reason, the doctor connected this with contraceptive Jess and advised me to purchase Novinet. The first month after the start of the reception, I did not have any side effects. True, menstruation, as they were meager, remained. But the condition of the skin and hair has improved. Reviews of women about Novinet also indicate a similar effect of the drug.
Before that, I had already heard that hormonal contraceptives can improve hair and pimples on the skin of the face, but when I used Jess, I did not notice this. Apparently, Novinet is a more modern drug. I want to advise all women to be sure to get a hormone test before taking such contraceptives. If there are any disruptions in hormones, then contraceptives can provoke the growth of hair on the face and body, as well as rapid body gain.
Marianna, Tver
I started taking this drug 4 years ago. The doctor prescribed me this remedy in order to dissolve the ovarian cyst. Six months later, I passed the tests, which showed that the cyst had really gone. But these six months were a real torment for me. I had almost all the side effects of Novinet. I constantly experienced discomfort in the lower abdomen and nausea in the morning. By the end of the course of treatment, I gained 12 kg of excess weight. So these hormonal contraceptives left me with an ambivalent impression.
On the one hand, they are really effective, they protect well from unwanted pregnancy and even cure some diseases, and on the other hand, they have a lot of side effects. It's been a year now and I still can't lose weight.
Maria, Omsk
About six years ago, I first started taking Novinet. Since you can’t constantly use it, so I took breaks for 2 months and continued to take birth control again. It is very important to use the tablets daily, at certain times of the day. Very often I heard the opinion that hormonal contraceptives reduce libido and lead to fullness. Nothing like this happened to me. When my husband and I wanted to have a baby, I simply stopped using Novita pills and got pregnant after 2 months.
This drug has many fans of different ages and good reviews. For women over 30 years old, Novinet is often recommended by gynecologists. At this age, the risk of developing many gynecological diseases increases. Modern oral contraceptives can cure many female diseases or prevent their occurrence. You can forget to take a pill and nothing will happen.
Larisa, Saransk
After the birth of my second child, I came to grips with the study of contraceptives. Since I really did not want an unplanned pregnancy, I approached the choice of pills very seriously. I immediately decided that I would only buy hormonal contraceptives. This is the most reliable way of protection. In second place are spirals, but they are not so reliable, they have more side effects. On one forum I read about Novinet and decided to buy it. The pills never let me down, I didn’t notice any side effects, although there are quite a lot of them described in the Novineta instructions.
Marina, Sochi
This drug was recommended to me by a gynecologist in a antenatal clinic. He recommended it as a very effective drug of a new generation. Before that, I had never used oral contraceptives, but only used condoms. From the first week I started having side effects. Very often attacks of nausea rolled up, shortness of breath appeared and sleep worsened. I constantly had frequent mood swings and a depressive state.
But then this condition passed, the condition of the skin improved markedly. She was very oily, but as soon as I started taking Novinet, my skin stopped getting oily and became absolutely normal. Also, all pimples and blackheads disappeared.
Before I started using Novinet, I took Charosetta. I switched to Novinet solely because of the price, but otherwise I was completely satisfied with Charosetta. And now for 2 years I have been using a new remedy. At first I had headaches, which I attributed to the new drug, but when I stopped using it, the pain did not go away. It turned out that these are not side effects of the drug. And I started taking it again.
Instructions for use Novineta gives a large list of side effects that may occur. But I didn't have any other symptoms. We can say that the drug completely suits me and I am not going to change it to another yet.
Valentina, Lipetsk
Novinet (ethinylestradiol + desogestrel) is a combined tableted contraceptive from the Hungarian pharmaceutical company GEDEON RICHTER. According to statistics, about 40% of women do not use pharmacological contraceptives. Meanwhile, from the point of view of embryology, human life begins with the fusion of the sex cells of a woman and a man, resulting in a nucleus containing a unique genetic material. And this new human organism can no longer be genetically considered an alien (i.e. maternal) part of the body. Thus, abortion should be considered the deliberate deprivation of the life of a new biological individual. Combined oral contraceptives have been used for decades. Progestogens of the first two generations do not have the proper level of selectivity of action. In addition, they are characterized by a number of undesirable side reactions, incl. arterial hypertension, lipid profile deterioration and insulin resistance. Desogestrel does not have the above disadvantages. This substance is one of the components of the drug Novinet. The estrogenic component in the preparation is ethinyl estradiol. Desogestrel is a 3rd generation progestogen. It has a high (more than 80% bioavailability). It undergoes metabolic transformations in the liver with the formation of an active derivative - 3-ketodesogestrel. Desogestrel shows the greatest degree of selectivity to progesterone receptors, which determines its powerful progestogenic effect.
At the same time, its androgenic and estrogenic effect is practically not manifested. Among all currently known progestogens, desogestrel has the highest selectivity index of action. Novine improves the lipid profile: it increases the blood levels of "good" cholesterol - high-density lipoproteins, without affecting the level of low-density lipoproteins. When using Novinet, blood loss during menstruation is significantly reduced, the condition of the skin improves, especially in the presence of acne. The effectiveness of Novinet as a contraceptive is associated with its ability to suppress the work of the ovaries, including inhibiting the formation of follicles. From this point of view, Novinet is one of the best contraceptives. The incidence of side effects when taking this contraceptive is relatively low. This happens, as a rule, during the first three months of pharmacotherapy, when the body adapts to functioning in new conditions. At the same time, side effects do not pose any threat to the health and well-being of the patient and almost completely disappear by the fourth cycle of contraceptive pharmacotherapy. A side effect characteristic of tableted contraceptives - an increase in body weight - in the case of Novinet appears much less frequently. The drug has very little effect on hemodynamics in the peripheral vascular bed, and therefore does not have a pronounced effect on blood pressure.
Pharmacology
A monophasic oral contraceptive containing a combination of an estrogen (ethinyl estradiol) and a progestogen (desogestrel). The main contraceptive action is the inhibition of gonadotropins and the suppression of ovulation. In addition, by increasing the viscosity of the cervical fluid, the movement of spermatozoa through the cervical canal slows down, and a change in the state of the endometrium prevents the implantation of a fertilized egg.
Ethinylestradiol is a synthetic analogue of the follicular hormone estradiol.
Desogestrel has a pronounced gestagenic and antiestrogenic effect, similar to endogenous progesterone, weak androgenic and anabolic activity.
The drug has a beneficial effect on lipid metabolism: it increases the content of HDL in plasma, without affecting the content of LDL.
When taking the drug, the loss of menstrual blood is significantly reduced (with initial menorrhagia), the menstrual cycle is normalized, and a beneficial effect on the skin is noted, especially in the presence of acne vulgaris.
Pharmacokinetics
Desogestrel
Suction
Desogestrel is rapidly and almost completely absorbed from the gastrointestinal tract and metabolized to 3-keto-desogestrel, which is the biologically active metabolite of desogestrel.
C max is reached after 1.5 h and is 2 ng / ml. Bioavailability - 62-81%.
Distribution
3-keto-desogestrel binds to plasma proteins, mainly albumin and sex hormone-binding globulin (SHBG).
V d is 1.5 l / kg. C ss is established by the second half of the menstrual cycle, when the level of 3-keto-desogestrel increases by 2-3 times.
Metabolism
In addition to 3-keto-desogestrel (which is formed in the liver and in the intestinal wall), other metabolites are formed: 3α-OH-desogestrel, 3β-OH-desogestrel, 3α-OH-5α-H-desogestrel (metabolites of the first phase). These metabolites do not have pharmacological activity and are partially, by conjugation (the second phase of metabolism), converted into polar metabolites - sulfates and glucuronates. Clearance from blood plasma is about 2 ml / min / kg of body weight.
breeding
T 1/2 is 30 hours. Metabolites are excreted in the urine and feces (in a ratio of 4:6).
Ethinylestradiol
Suction
Ethinylestradiol is rapidly and completely absorbed from the gastrointestinal tract. C max is achieved 1-2 hours after taking the drug and is 80 pg / ml. The bioavailability of the drug due to presystemic conjugation and the effect of "first pass" through the liver is about 60%.
Distribution
Ethinylestradiol is completely bound to plasma proteins, mainly to albumins.
Vd is 5 l/kg. C ss is established by 3-4 days of administration, while the level of ethinylestradiol in serum is 30-40% higher than after a single dose of the drug.
Metabolism
Presystemic conjugation of ethinylestradiol is significant. Bypassing the intestinal wall (first phase of metabolism), it undergoes conjugation in the liver (second phase of metabolism). Ethinylestradiol and its conjugates of the first phase of metabolism (sulfates and glucuronides) are excreted into the bile and enter the enterohepatic circulation. Clearance from blood plasma is about 5 ml / min / kg of body weight.
breeding
T1 / 2 ethinylestradiol averages about 24 hours. About 40% is excreted in the urine and about 60% in the feces.
Release form
Light yellow film-coated tablets, round, biconvex, marked "P9" on one side and "RG" on the other.
Excipients: quinoline yellow dye (E104), α-tocopherol, magnesium stearate, colloidal silicon dioxide, stearic acid, povidone, potato starch, lactose monohydrate.
The composition of the film shell: propylene glycol, macrogol 6000, hypromellose.
21 pcs. - blisters (1) - packs of cardboard.
21 pcs. - blisters (3) - packs of cardboard.
Dosage
The drug is prescribed inside.
Reception of tablets is begun from the 1st day of a menstrual cycle. Assign 1 tablet / day for 21 days, if possible at the same time of day. After taking the last pill from the package, a 7-day break is taken, during which menstrual-like bleeding occurs due to drug withdrawal. The next day after a 7-day break (4 weeks after taking the first tablet, on the same day of the week), the drug is resumed from the next package, also containing 21 tablets, even if the bleeding has not stopped. This scheme of taking pills is followed as long as there is a need for contraception. Subject to the rules of admission, the contraceptive effect persists for the duration of the 7-day break.
First dose of the drug
The first tablet should be taken from the first day of the menstrual cycle. In this case, you do not need to use additional methods of contraception. You can start taking pills from the 2-5th day of menstruation, but in this case, in the first cycle of using the drug, additional methods of contraception should be used in the first 7 days of taking the pills.
If more than 5 days have passed since the start of menstruation, you should postpone the start of taking the drug until the next menstruation.
Taking the drug after childbirth
Women who are not breastfeeding can start taking pills no earlier than 21 days after giving birth, after consulting with their doctor. In this case, there is no need to use other methods of contraception. If after childbirth there was already sexual contact, then taking the pills should be postponed until the first menstruation. If a decision is made to take the drug later than 21 days after birth, then in the first 7 days it is necessary to use additional methods of contraception.
Taking the drug after an abortion
After an abortion, in the absence of contraindications, pills should be started from the first day after the operation, and in this case there is no need to use additional methods of contraception.
Switching from another oral contraceptive
After using another hormonal oral contraceptive containing 30 mcg of ethinylestradiol, according to a 21-day regimen, the first Novinet tablet is recommended to be taken the next day after completing the course of the previous drug. It is not required to withstand a 7-day break or wait for the onset of menstruation. There is no need to use additional methods of contraception.
When switching from a preparation containing 28 tablets, the next day after the tablets in the package have ended, you should start a new package of Novinet ® .
Switching to Novinet after using progestogen-only oral hormonal preparations ("mini-pill")
The first tablet of Novinet ® should be taken on the 1st day of the cycle. There is no need to use additional methods of contraception.
If menstruation does not occur when taking the "mini-pill", then after the exclusion of pregnancy, you can start taking Novinet on any day of the cycle, but in this case, additional methods of contraception must be used in the first 7 days (use of a cervical cap with spermicidal gel, a condom, or abstinence from sexual intercourse). The use of the calendar method in these cases is not recommended.
Postponement of the menstrual cycle
If there is a need to delay menstruation, it is necessary to continue taking the tablets from the new package, without a 7-day break, according to the usual scheme. With a delay in menstruation, breakthrough or spotting bleeding may occur, but this does not reduce the contraceptive effect of the drug. Regular reception of Novinet can be restored after the usual 7-day break.
Missed pills
If a woman forgot to take a pill in a timely manner, and no more than 12 hours have passed after the missed one, you need to take the forgotten pill, and then continue taking it at the usual time. If more than 12 hours have passed between taking the pills - this is considered a missed pill, the reliability of contraception in this cycle is not guaranteed and the use of additional methods of contraception is recommended.
If you skip one tablet in the first or second week of the cycle, you need to take 2 tablets. the next day and then continue regular intake using additional methods of contraception until the end of the cycle.
If you miss a pill in the third week of the cycle, you must take the forgotten pill, continue to take it regularly and do not take a 7-day break. It is important to remember that due to the minimum dose of estrogen, the risk of ovulation and / or bleeding increases when a pill is missed, and therefore the use of additional methods of contraception is recommended.
Vomiting/diarrhea
If vomiting or diarrhea occurs after taking the drug, then the absorption of the drug may be defective. If the symptoms have stopped within 12 hours, then you need to take another tablet in addition. After that, you should continue taking the tablets in the usual way. If vomiting or diarrhea continues for more than 12 hours, then additional methods of contraception should be used during vomiting or diarrhea and for the next 7 days.
Overdose
Symptoms: nausea, vomiting, in girls - bloody discharge from the vagina.
Treatment: in the first 2-3 hours after taking the drug in a high dose, gastric lavage is recommended. There is no specific antidote, treatment is symptomatic.
Interaction
Drugs that induce liver enzymes, such as hydantoin, barbiturates, primidone, carbamazepine, rifampicin, oxcarbazepine, topiramate, felbamate, griseofulvin, St. John's wort, reduce the effectiveness of oral contraceptives and increase the risk of breakthrough bleeding. The maximum level of induction is usually reached no earlier than 2-3 weeks, but may last up to 4 weeks after discontinuation of the drug.
Ampicillin and tetracycline reduce the effectiveness of Novinet (the mechanism of interaction has not been established). If co-administration is necessary, it is recommended to use an additional barrier method of contraception throughout the course of treatment and for 7 days (for rifampicin - within 28 days) after discontinuation of the drug.
Oral contraceptives may decrease carbohydrate tolerance, increase the need for insulin or oral antidiabetic agents.
Side effects
Side effects requiring discontinuation of the drug
From the side of the cardiovascular system: arterial hypertension; rarely - arterial and venous thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism); very rarely - arterial or venous thromboembolism of the hepatic, mesenteric, renal, retinal arteries and veins.
From the senses: hearing loss due to otosclerosis.
Others: hemolytic uremic syndrome, porphyria; rarely - exacerbation of reactive systemic lupus erythematosus; very rarely - Sydenham's chorea (passing after discontinuation of the drug).
Other side effects are more common but less severe. The expediency of continuing the use of the drug is decided individually after consultation with a doctor, based on the benefit / risk ratio.
On the part of the reproductive system: acyclic bleeding / bloody discharge from the vagina, amenorrhea after discontinuation of the drug, changes in the state of vaginal mucus, the development of inflammatory processes in the vagina, candidiasis, tension, pain, enlargement of the mammary glands, galactorrhea.
From the digestive system: nausea, vomiting, Crohn's disease, ulcerative colitis, the occurrence or exacerbation of jaundice and / or itching associated with cholestasis, cholelithiasis.
Dermatological reactions: erythema nodosum, erythema exudative, rash, chloasma.
From the side of the central nervous system: headache, migraine, mood lability, depression.
On the part of the organ of vision: increased sensitivity of the cornea (when wearing contact lenses).
On the part of metabolism: fluid retention in the body, change (increase) in body weight, decreased tolerance to carbohydrates.
Other: allergic reactions.
Indications
Contraception.
Contraindications
- the presence of severe and / or multiple risk factors for venous or arterial thrombosis (including severe or moderate arterial hypertension with blood pressure ≥ 160/100 mm Hg);
- the presence or indication in the anamnesis of the precursors of thrombosis (including transient ischemic attack, angina pectoris);
- migraine with focal neurological symptoms, incl. in history;
- venous or arterial thrombosis / thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower leg, pulmonary embolism) at present or in history;
- the presence of venous thromboembolism in history;
- diabetes mellitus (with angiopathy);
- pancreatitis (including history), accompanied by severe hypertriglyceridemia;
- dyslipidemia;
- severe liver disease, cholestatic jaundice (including during pregnancy), hepatitis, incl. in history (before the normalization of functional and laboratory parameters and within 3 months after their normalization);
- jaundice when taking GCS;
- cholelithiasis at present or in history;
- Gilbert's syndrome, Dubin-Johnson syndrome, Rotor's syndrome;
- liver tumors (including history);
- severe itching, otosclerosis or its progression during a previous pregnancy or taking corticosteroids;
- hormone-dependent malignant neoplasms of the genital organs and mammary glands (including if they are suspected);
- vaginal bleeding of unknown etiology;
- smoking over the age of 35 (more than 15 cigarettes per day);
- pregnancy or suspicion of it;
- lactation period;
- hypersensitivity to the components of the drug.
The drug should be prescribed with caution in conditions that increase the risk of developing venous or arterial thrombosis / thromboembolism: age over 35 years, smoking, family history, obesity (body mass index more than 30 kg / m 2), dyslipoproteinemia, arterial hypertension, migraine, epilepsy, valvular heart disease, atrial fibrillation, prolonged immobilization, extensive surgery, surgical intervention on lower extremities, severe trauma, varicose veins and superficial thrombophlebitis, postpartum period, severe depression (including a history), changes in biochemical parameters (activated protein C resistance, hyperhomocysteinemia, antithrombin III deficiency, protein C or S deficiency, antiphospholipid antibodies, including antibodies to cardiolipin, lupus anticoagulant), diabetes mellitus, uncomplicated vascular disorders, SLE, Crohn's disease, ulcerative colitis, sickle cell anemia, hypertriglyceridemia (including family history), acute and chronic liver disease.
Application features
Use during pregnancy and lactation
Novinet ® is contraindicated for use during pregnancy and lactation (breastfeeding).
Application for violations of liver function
Contraindicated in severe liver disease, cholestatic jaundice (including during pregnancy), hepatitis, incl. in history (before the normalization of functional and laboratory parameters and within 3 months after their normalization). With caution, the drug should be prescribed for acute and chronic liver diseases.Application for violations of kidney function
With caution and only after a thorough assessment of the benefits and risks of use, the drug should be prescribed for renal failure (including history),special instructions
Before starting the use of the drug, it is necessary to conduct a general medical (detailed family and personal history, measurement of blood pressure, laboratory tests) and gynecological examination (including examination of the mammary glands, pelvic organs, cytological analysis of a cervical smear). A similar examination during the period of taking the drug is carried out regularly, every 6 months.
The drug is a reliable contraceptive: the Pearl index (an indicator of the number of pregnancies that occurred during the use of a contraceptive method in 100 women for 1 year), when used correctly, is about 0.05.
In each case, before prescribing hormonal contraceptives, the benefits or possible negative effects of their use are individually assessed. This issue must be discussed with the patient, who, after receiving the necessary information, will make the final decision on the preference for hormonal or any other method of contraception.
The state of health of women must be carefully monitored. If any of the following conditions / diseases appear or worsen while taking the drug, you must stop taking the drug and switch to another, non-hormonal method of contraception:
- diseases of the hemostasis system;
- conditions/diseases predisposing to the development of cardiovascular, renal failure;
- epilepsy;
- migraine;
- the risk of developing an estrogen-dependent tumor or estrogen-dependent gynecological diseases;
- diabetes mellitus, not complicated by vascular disorders;
- severe depression (if depression is associated with impaired tryptophan metabolism, then vitamin B 6 can be used for correction);
- sickle cell anemia, tk. in some cases (for example, infections, hypoxia), estrogen-containing drugs in this pathology can provoke thromboembolism;
- the appearance of abnormalities in laboratory tests for assessing liver function.
Thromboembolic diseases
Epidemiological studies have shown that there is a connection between taking oral hormonal contraceptives and an increased risk of developing arterial and venous thromboembolic diseases (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism). An increased risk of venous thromboembolic disease has been proven, but it is significantly less than during pregnancy (60 cases per 100,000 pregnancies). When using oral contraceptives, arterial or venous thromboembolism of the hepatic, mesenteric, renal or retinal vessels is very rarely observed.
The risk of developing arterial or venous thromboembolic diseases increases:
- with age;
- when smoking (heavy smoking and age over 35 are risk factors);
- if there is a family history of thromboembolic diseases (for example, in parents, a brother or sister). If a genetic predisposition is suspected, it is necessary to consult a specialist before using the drug;
- with obesity (body mass index more than 30 kg / m 2);
- with dyslipoproteinemia;
- with arterial hypertension;
- in diseases of the heart valves, complicated by hemodynamic disorders;
- with atrial fibrillation;
- with diabetes mellitus complicated by vascular lesions;
- with prolonged immobilization, after major surgery, after surgery on the lower extremities, after a severe injury.
In these cases, a temporary discontinuation of the drug is expected (no later than 4 weeks before surgery, and resumed no earlier than 2 weeks after remobilization).
Women after childbirth have an increased risk of venous thromboembolic disease.
It should be borne in mind that diabetes mellitus, systemic lupus erythematosus, hemolytic-uremic syndrome, Crohn's disease, ulcerative colitis, sickle cell anemia increase the risk of developing venous thromboembolic diseases.
It should be borne in mind that resistance to activated protein C, hyperhomocysteinemia, deficiency of proteins C and S, deficiency of antithrombin III, the presence of antiphospholipid antibodies increase the risk of developing arterial or venous thromboembolic diseases.
When assessing the benefit / risk ratio of taking the drug, it should be taken into account that targeted treatment of this condition reduces the risk of thromboembolism. The symptoms of thromboembolism are:
- sudden chest pain that radiates to the left arm;
- sudden shortness of breath;
- any unusually severe headache that lasts for a long time or appears for the first time, especially when combined with sudden complete or partial loss of vision or diplopia, aphasia, dizziness, collapse, focal epilepsy, weakness or severe numbness of one side of the body, movement disorders, severe unilateral pain in the calf muscle, acute abdomen.
Tumor diseases
Some studies have reported an increase in the incidence of cervical cancer in women who have taken hormonal contraceptives for a long time, but the results of the studies are conflicting. Sexual behavior, human papillomavirus infection and other factors play a significant role in the development of cervical cancer.
A meta-analysis of 54 epidemiological studies showed that there is a relative increase in the risk of breast cancer among women taking oral hormonal contraceptives, but the higher detection of breast cancer could be associated with more regular medical examinations. Breast cancer is rare among women under 40, whether they are taking hormonal birth control or not, and increases with age. Taking pills can be regarded as one of many risk factors. However, women should be advised of the potential risk of developing breast cancer based on a benefit-risk assessment (protection against ovarian and endometrial cancer).
There are few reports of the development of benign or malignant liver tumors in women who take hormonal contraceptives for a long time. This should be kept in mind in the differential diagnostic evaluation of abdominal pain, which may be associated with an increase in the size of the liver or intraperitoneal bleeding.
Chloasma can develop in women who have a history of this disease during pregnancy. Those women who are at risk of developing chloasma should avoid contact with sunlight or ultraviolet radiation while taking Novinet.
Efficiency
The effectiveness of the drug may decrease in the following cases: missed pills, vomiting and diarrhea, simultaneous use of other drugs that reduce the effectiveness of birth control pills.
If the patient is simultaneously taking another drug that can reduce the effectiveness of birth control pills, additional methods of contraception should be used.
The effectiveness of the drug may decrease if, after several months of their use, irregular, spotting or breakthrough bleeding appears, in such cases it is advisable to continue taking the tablets until they are finished in the next package. If at the end of the second cycle, menstrual bleeding does not begin or acyclic spotting does not stop, stop taking the tablets and resume it only after pregnancy has been ruled out.
Changes in laboratory parameters
Under the influence of oral contraceptive pills - due to the estrogen component - the level of some laboratory parameters (functional parameters of the liver, kidneys, adrenal glands, thyroid gland, hemostasis indicators, levels of lipoproteins and transport proteins) may change.
Additional Information
After suffering acute viral hepatitis, the drug should be taken after normalization of liver function (not earlier than after 6 months).
With diarrhea or intestinal disorders, vomiting, the contraceptive effect may decrease. Without stopping taking the drug, it is necessary to use additional non-hormonal methods of contraception.
Women who smoke have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk depends on age (especially in women over 35) and on the number of cigarettes smoked.
A woman should be warned that the drug does not protect against HIV infection (AIDS) and other sexually transmitted diseases.
Influence on the ability to drive vehicles and control mechanisms
No studies have been conducted to study the effect of Novineta on the ability to drive and operate machinery.
Content
Oral contraception is considered a convenient and effective way to protect against unwanted pregnancy. The drug is selected individually, depending on the hormonal background of the woman. Contraceptive pills "Novinet" belong to the category of monophasic low-dose drugs. Most often they are prescribed to nulliparous women.
Compound
"Novinet" is produced in the form of tablets intended for oral administration. The contraceptive effect is due to the content of desogestrel (150 mcg) and ethinylestradiol (20 mcg). The auxiliary components of the drug include:
- hypromellose;
- octadecanoic acid;
- alpha-tocopherol;
- macrogol 6000;
- magnesium stearate;
- starch;
- povidone;
- lactose;
- colloidal silicon dioxide.
Pharmacotherapeutic group and properties
The contraceptive effect of "Novinet" is achieved due to the content of derivatives of progestogen and estrogen. Their entry into the body blocks the production of sex hormones responsible for the maturation of the egg. The active components of the drug also affect the viscosity of cervical mucus. As a result, spermatozoa cannot fully move through the female genital tract.
While taking a contraceptive, the functional activity of the inner layer of the uterus changes. It does not grow to the desired size, which makes the process of attaching the embryo impossible. In addition to the main action, Novinet increases the concentration of high density lipoproteins. This prevents the deposition of cholesterol plaques in the cavity of the vessels. As a result of taking Novinet, a woman notices:
- decrease in the volume of menstrual flow;
- stabilization of the menstrual cycle;
- lowering the risk of developing tumor-like processes;
- improving the quality of the skin;
- disappearance of PMS symptoms.
Desogestrel, which is part of the drug, has a positive effect on lipid metabolism. It evens out the level of cholesterol in the body and normalizes the lipid profile. Both active components of the contraceptive are characterized by rapid binding to plasma proteins. Their maximum amount in the blood is observed approximately 90 minutes after taking the pill.
Indications and contraindications
Contraceptive pills "Novinet" are used to prevent unwanted pregnancy. In some cases, it is prescribed for medicinal purposes - to improve the quality of the skin and normalize the cycle. Contraindications include the following:
- deviations in the work of the liver;
- venous thromboembolism or thrombosis;
- the presence of hormone-dependent tumors;
- an allergic reaction to the constituent components;
- diabetes mellitus, accompanied by vascular pathologies;
- pancreatitis;
- otosclerosis;
- prone to migraines.
Important! "Novinet" is taken only as directed by a doctor, after passing the appropriate tests.
Instructions for contraceptive pills Novinet
Contraceptive pills "Novinet" drink strictly in accordance with the instructions. One package is enough for 1 menstrual cycle. Each tablet in the blister is numbered. This allows you to exercise full control over the intake of contraceptives.
When taking a contraceptive, it must be taken into account that antibiotics and preparations containing St. John's wort reduce the contraceptive effect. Severe vomiting and diarrhea are equated to missing a pill if it happened within 4 hours after taking the contraceptive. The active ingredients do not have time to be completely absorbed into the mucous membrane of the digestive system completely. In this case, it is necessary to follow the instructions, as in the case of skipping dragees.
Mode of application
Taking the drug begins on the 1st day of the menstrual cycle. Pills are taken 1 piece per day, at the same time of day. The duration of admission is 3 weeks. Then there is a week break. During it, a woman has spotting. After the break, the next pack begins, even if the period has not ended.
You can start taking the first pack of contraceptives from day 1 to day 5 of the cycle. If a woman started taking the drug after the 2nd day, then additional methods of contraception should be used in the first week. If more than a week has passed since the start of menstruation, it is forbidden to take pills.
Sometimes pills are used to delay menstruation. In this case, a 7-day break when switching from one pack to another is not done. But this method of transferring menstruation is allowed to be practiced infrequently and only with the permission of the gynecologist.
Warning! It is strictly forbidden to stop taking the drug ahead of time.
What to do if you missed 1 birth control pill Novinet
When skipping the Novinet birth control pill, a woman should take the next one as soon as she remembers it. If more than 36 hours have passed since the previous pill was taken, the drug is taken according to the previous scheme. But in this case, additional methods of contraception are needed, since the contraceptive effect is reduced.
Skipping a tablet at 1-2 weeks of hormone therapy indicates the need to take 2 tablets at once. In this case, the woman may experience breakthrough bleeding.
How to switch from Regulon to Novinet
An analogue of "Novinet" are contraceptive pills "Regulon". They belong to the category of monophasic contraceptives with pronounced progestogenic and antiestrogenic effects. Very often, doctors replace Regulon with Novinet, since the drugs are identical and are in the same price category.
When switching from Regulon to Novinet, you do not need to take a 7-day break. The first Novinet tablet is taken the next day after taking the last Regulon pill. The degree of contraceptive effect in this case is not reduced. Instead of menstruation, there may be a spotting discharge.
Side effects
During the use of birth control pills, a woman may experience unpleasant symptoms. Their appearance in the first 3 months of admission is due to the adaptation of the body. The most common side effects include:
- headache;
- sudden change of mood;
- fluid retention in the body;
- ulcerative colitis;
- depressive state;
- thrush;
- change in carbohydrate tolerance;
- nausea and vomiting;
- weight gain;
- increased sensitivity of the pupil to contact lenses.
In some cases, severe side effects develop with the use of birth control pills. Their appearance indicates the need to cancel the contraceptive. Warning symptoms include:
- porphyria;
- blockage of the vein cavity with blood clots;
- hypertension;
- hearing loss.
Attention! If side effects are detected, a woman needs to visit a doctor to select an alternative drug.
Pregnancy and lactation
During the bearing of a child, the use of birth control pills is prohibited. The contraceptive effect during this period is inappropriate. During the lactation period, Novinet cannot be used due to the penetration of its active components into breast milk. After labor, "Novinet" is allowed to be taken no earlier than six months later.
Terms and conditions of storage
The drug is suitable for use within 3 years after manufacture. The production date is indicated on the end of the package. It is required to store medicine in the place protected from children at a temperature from 15 to 30 °C.
The price of contraceptive pills Novinet
The price of contraceptive "Novinet" is directly dependent on the number of pills in a pack. The cost of 21 tablets ranges from 260 to 470 rubles. A package for 3 months can be bought for 1100-2300 rubles, depending on the location of the pharmacy. In large cities, tablet prices are higher.
Analogues
"Novinet" is replaced by an analogue in the event that the drug is not suitable for a woman. This is evidenced by the appearance of side effects. The alternatives closest in composition and action include:
- "Regulon";
- "Lindinet 20";
- "Yarina";
- "Janine";
- "Dimia";
- "Jess".
When choosing a replacement for Novinet, the doctor focuses on the woman's hormonal background, age, number of pregnancies and childbirth. The first 3 months of use is called the adaptation period. If a woman feels well, then the pills are suitable for her.
Novinet or Regulon: which is better
The main difference between "Regulon" and "Novinet" is the concentration of the active substance. Compared to Novinet, in Regulon the level of desogestrel is higher. It is 30 mcg. Otherwise, birth control pills are almost identical. At the price of Novinet, it is 60-80 rubles more expensive than Regulon. Therefore, preference is most often given to the latter.
Novinet or Lindinet 20: which is better
"Lindinet 20" differs from "Novinet" in composition. In addition to ethinylestradiol, gestodene acts as an active component. It is a synthetic progestin that is more effective than levonorgestrel and progesterone. It is impossible to judge which of the presented drugs is better. Moreover, the cost of drugs is almost the same. Contraceptive pills are selected individually.
Novinet or Jess: which is better
The composition of the tablets "Jess" includes: drospirenone (3 mg) and ethinyl estradiol (20 mcg). The drug, like Novinet, is classified as a low-dose contraceptive. A distinctive feature of the drug is the content of 28 tablets. Therefore, there is no need to take a break between packs. "Jess" not only has a contraceptive effect, but also cares for the skin of the face. It is prescribed if a woman suffers from acne. The average price of the drug is 1100 rubles.
Novinet or Yarina: which is better
"Yarina" is united with "Novinet" by the presence of ethinyl estradiol in the composition. The drug also includes: calcium levomefolate and drospirenone. "Novinet" is most often prescribed to women under the age of 25 years. "Yarina" has no age restrictions. The price for a pack of tablets is 1000-2000 rubles.
Novinet or Jeanine: which is better
Janine is a monophasic contraceptive taken by women of childbearing age to protect against pregnancy. In diabetes mellitus, liver failure, thrombosis and vaginal bleeding, the drug is contraindicated. From "Novinet" tablets "Janine" distinguishes the content of dienogest in the amount of 2 mg. Drugs can act as a full replacement for each other. The average cost of a package of 21 tablets is 1070 rubles.
Which is better: Novinet or Qlaira
In terms of its constituent components, the Qlaira tablets are similar to Novinet. After taking 21 tablets, there is no need to take a break, since the package contains 28 pieces. According to statistics, Qlaira is better tolerated by the female body. The likelihood of side effects if it is taken is lower. The cost of a package for a month of admission is 1200 rubles.
Novinet or Dimia: which is better
"Dimia" belongs to the category of monophasic contraceptives. The action of the drug is aimed at blocking ovulation and thickening the cervical mucus. The composition of the contraceptive pills "Dimia" includes: drospirenone, ethinyl estradiol. Like Novinet, the drug is produced in Hungary. Since the concentration of hormones in "Dimia" is higher, it is prescribed to women of mature age. Reception "Novinet" is more relevant for young girls. The price of a package of "Dimia" of 28 tablets is 600-700 rubles.
Conclusion
Contraceptive pills "Novinet" are popular due to the affordable cost and low concentration of active ingredients. Most often they are prescribed to girls under 25 years old. The drug rarely provokes the appearance of side effects and health complications. It is used both for medicinal purposes and to achieve a contraceptive effect.
In the families of our not so distant ancestors, the absolute norm was to have about ten children. People gave birth to babies as much as God gave them and rarely tried to prevent unwanted pregnancy or simply did not have such an opportunity. Today, fortunately, each family can independently decide how many children it will have. The modern contraceptive market presents a variety of contraceptive options for every taste and budget. One of the rather popular drugs of this type is Novinet, the use of which, as well as side effects, possible substitutions, contraindications, we will consider today. In general, let's talk about the features of this medicinal composition.
What is the action of Novinet?
This drug belongs to the combined hormonal contraceptives intended for oral consumption. It is a monophasic composition that includes synthetic hormones such as desogestrel, as well as ethinyl estradiol estrogen. Due to the ultra-low dosage of the components, Novinet is considered to be a micro-dosed contraceptive composition. The consumption of this composition leads to the suppression of ovulatory processes, as well as to a change in the characteristics of the endometrium and thickening of the mucus produced by the uterine neck (this makes it difficult for sperm to penetrate through it).
In addition to the contraceptive effect, Novinet also has a positive effect on the activity of the entire reproductive system. It normalizes and evens out the menstrual cycle, reduces blood loss during menstruation, and reduces existing inflammatory processes inside the female genital organs. Also, long-term consumption of this medicinal composition can improve the condition of the skin, and this is especially noticeable with acne.
Also, the use of this composition helps to somewhat reduce the likelihood of an ectopic pregnancy, the development of tumor processes inside the breast, ovaries and endometrium.
How to use Novinet, how to take?
The use of Novinet must be started on the very first day of the cycle (with the onset of menstruation). Every day you need to drink one tablet of the medicine, preferably at the same time of day. Duration of admission - twenty-one days, in accordance with the instructions on the blister.
After completing a three-week course, it is important to take a break for one week, then, at the end of it, you must start consuming the medicine from the next package. The resumption of the course should take place on the same day of the week as the initial medication.
During a week-long pause, menstrual bleeding usually starts, and the consumption of tablets must be resumed, regardless of whether it has stopped or not.
In the event that you forgot to take a pill on the first day of menstruation, this can be done on the second and even on the fifth day, but in this case, the effectiveness of the drug will be reduced. Therefore, it is recommended to use additional contraceptives for one week, which will provide the most reliable protection against pregnancy.
After the abortion, Novinet begins to be used the next day after surgery.
It is worth considering that the interval between the consumption of the drug should not exceed twenty-four hours, respectively, if you skip a dose, you need to drink two tablets at once. At the same time, if the pause between doses has exceeded thirty-six hours, you will need to resort to additional methods of protection and be more careful next time.
What are the side effects of Novinet?
The likelihood of side effects is quite small. Since the drug contains a minimal amount of an estrogen component, the patient may experience intermenstrual bleeding, or spotting in the middle of the cycle. One of the methods of preventing such a phenomenon is considered to be careful observance of all the rules for the consumption of the drug, namely, taking it exclusively at the same time of day without a pass. In some cases, the medicine can provoke the development of nausea and even vomiting, headache and some discomfort in the chest. Quite rarely, patients note an increase in weight while taking Novinet, as well as a decrease in lshibido. There may be a problem of depressed mood, and when using contact lenses, some discomfort when wearing them. Most of the time, these symptoms are temporary. They go away on their own after about a couple of months after starting to use the drug.
With prolonged use of Novinet, other side effects may develop, such as the appearance of age spots on the surface of the skin. Quite rarely, there is an increase in blood pressure, the occurrence of thrombosis, or thromboembolism of different localization. Rare side effects also include gallbladder lesions, jaundice, rashes on the surface of the skin, intense hair loss, changes in vaginal secretion. Sometimes the drug provokes the development of fungal infections of the vagina, the appearance of increased fatigue and diarrhea.
It should be borne in mind that the use of the drug Novinet is possible only after consulting a doctor. The specialist must examine the patient, collect an anamnesis and prescribe a series of studies, including testing for hormone levels. Only in this case, the drug will not harm health and will be really effective.
Tablets Novinet instructions for use refers to monophasic oral contraceptives. The medicine is taken as an oral contraceptive to prevent unwanted pregnancy in women of reproductive (childbearing) age. Why Novinet is prescribed, prices, reviews of patients and doctors, as well as analogues of the drug will be discussed in the article.
Composition and form of release
Dosage form - film-coated tablets: round, biconvex, light yellow, marked "RG" on one side, "P9" on the other (21 pieces in blisters, in a carton pack 1 or 3 blisters). The content of active ingredients in 1 tablet "Novineta":
- Ethinylestradiol - 20 mcg.
- Desogestrel - 150 mcg.
Pharmacological effects
"Novinet", instructions for use reports this, is a monophasic hormonal contraceptive drug for oral administration, containing a combination of estrogen (ethinyl estradiol) and progestogen (desogestrel).
The main contraceptive action is the inhibition of gonadotropins and the suppression of ovulation. In addition, by increasing the viscosity of the cervical fluid, the movement of spermatozoa through the cervical canal slows down, and a change in the state of the endometrium prevents the implantation of a fertilized egg.
Ethinylestradiol is a synthetic analogue of the follicular hormone estradiol. Desogestrel has a pronounced gestagenic and antiestrogenic effect, similar to endogenous progesterone, weak androgenic and anabolic activity.
The drug has a beneficial effect on lipid metabolism: it increases the content of HDL in plasma, without affecting the content of LDL. When taking the medication, the loss of menstrual blood is significantly reduced (with initial menorrhagia), the menstrual cycle is normalized, and a beneficial effect on the skin is noted, especially in the presence of acne vulgaris (pimples).
What helps "Novinet"?
The use of "Novinet" is shown to women for oral contraception.
Important! Only a doctor should decide on the need for course pharmacotherapy. Self-medication is absolutely unacceptable.
Contraindications
- Dyslipidemia.
- Diabetes mellitus (with angiopathy).
- Angina pectoris, transient ischemic attack and other precursors of thrombosis (including when indicated in history).
- Dubin-Johnson syndrome, Gilbert's syndrome, Rotor's syndrome.
- Severe pruritus, otosclerosis and its progression while taking GCS or during a previous pregnancy.
- The period of pregnancy, including the suspicion of it.
- Migraine with focal neurological symptoms, including history.
- Liver neoplasms, including history.
- Gallstone disease, including history.
- Breast-feeding.
- Myocardial infarction, deep vein thrombosis of the lower leg, stroke, pulmonary embolism and other forms of venous or arterial thrombosis or thromboembolism at present and in history.
- Hormone-dependent malignant tumors of the mammary glands and genital organs or suspicion of them.
- Arterial hypertension of moderate or severe degree (blood pressure (BP) 160/100 mm Hg or more) and other multiple and / or pronounced risk factors for arterial or venous thrombosis.
- Jaundice on the background of glucocorticosteroids (GCS).
- Smoking more than 15 cigarettes per day over the age of 35.
- Hypersensitivity to the components of the drug.
- History of venous thromboembolism.
- Pancreatitis (including history), occurring with severe hypertriglyceridemia.
- Vaginal bleeding of unknown origin.
- Severe liver disease, cholestatic jaundice (including during pregnancy), hepatitis, including history (before normalization of laboratory and functional parameters and within 3 months after it).
Instructions for use
"Novinet" is prescribed inside. Reception of tablets is begun from the 1st day of a menstrual cycle. Assign 1 tablet per day for 21 days, if possible at the same time of day. After taking the last pill from the package, a 7-day break is taken, during which menstrual-like bleeding occurs due to drug withdrawal.
The next day after a 7-day break (4 weeks after taking the first tablet, on the same day of the week), the drug is resumed from the next package, also containing 21 tablets, even if the bleeding has not stopped. This scheme of taking pills is followed as long as there is a need for contraception. Subject to the rules of admission, the contraceptive effect persists for the duration of the 7-day break.
First dose of the drug
The first tablet should be taken from the first day of the menstrual cycle. In this case, you do not need to use additional methods of contraception.
You can start taking pills from the 2-5th day of menstruation, but in this case, in the first cycle of using the drug, additional methods of contraception should be used in the first 7 days of taking the pills. If more than 5 days have passed since the start of menstruation, you should postpone the start of taking the drug until the next menstruation.
Taking the drug after childbirth
Women who are not breastfeeding can start taking pills no earlier than 21 days after giving birth, after consulting with their doctor. In this case, there is no need to use other methods of contraception. If after childbirth there was already sexual contact, then taking the pills should be postponed until the first menstruation.
If a decision is made to take the drug later than 21 days after birth, then in the first 7 days it is necessary to use additional methods of contraception.
Taking the drug after an abortion
After an abortion, in the absence of contraindications, pills should be started from the first day after the operation, and in this case there is no need to use additional methods of contraception.
Switching from another oral contraceptive
After using another hormonal oral contraceptive containing 30 mcg of ethinylestradiol, according to a 21-day regimen, the first Novinet tablet is recommended to be taken the next day after completing the course of the previous drug.
It is not required to withstand a 7-day break or wait for the onset of menstruation. There is no need to use additional methods of contraception. When switching from a preparation containing 28 tablets, the next day after the tablets in the package have run out, a new Novinet package should be started.
Transition after using progestogen-only oral hormonal preparations ("mini-pill")
The first Novinet tablet should be taken on the 1st day of the cycle. There is no need to use additional methods of contraception. If menstruation does not occur when taking the "mini-pill", then after the exclusion of pregnancy, you can start taking "Novinet" on any day of the cycle, but in this case, additional methods of contraception must be used in the first 7 days (use of a cervical cap with spermicidal gel, a condom, or abstinence from sexual intercourse).
The use of the calendar method in these cases is not recommended.
Postponement of the menstrual cycle
If there is a need to delay menstruation, it is necessary to continue taking the tablets from the new package, without a 7-day break, according to the usual scheme. With a delay in menstruation, breakthrough or spotting bleeding may occur, but this does not reduce the contraceptive effect of the drug.
Regular reception of "Novinet" can be restored after the usual 7-day break.
Missed pills
If a woman forgot to take a pill in a timely manner, and no more than 12 hours have passed after the missed one, you need to take the forgotten pill, and then continue taking it at the usual time. If more than 12 hours have passed between taking the pills, this is considered a missed pill, the reliability of contraception in this cycle is not guaranteed and the use of additional methods of contraception is recommended.
If one tablet is missed in the first or second week of the cycle, it is necessary to take 2 tablets the next day and then continue regular intake using additional methods of contraception until the end of the cycle. If you miss a pill in the third week of the cycle, you must take the forgotten pill, continue to take it regularly and do not take a 7-day break.
It is important to remember that due to the minimum dose of estrogen, the risk of ovulation and / or bleeding increases when a pill is missed, and therefore the use of additional methods of contraception is recommended.
Vomiting or nausea
If vomiting or diarrhea occurs after taking the drug, then the absorption of the drug may be defective. If the symptoms have stopped within 12 hours, then you need to take another tablet in addition. After that, you should continue taking the tablets in the usual way.
If vomiting or diarrhea continues for more than 12 hours, then additional methods of contraception should be used during vomiting or diarrhea and for the next 7 days.
Side effects
The negative effects of "Novinet" are manifested:
- headaches;
- nodular or exudative erythema;
- ulcerative colitis;
- hypersensitivity reactions;
- jaundice and/or pruritus associated with cholestasis;
- depression
- soreness, tension and enlargement of the mammary glands, the release of milk from them;
- change in the state of mucus in the vagina;
- decreased tolerance to carbohydrates;
- vomiting;
- the development of inflammatory processes in the vagina;
- fluid retention in the body;
- increased sensitivity of the cornea to contact lenses;
- changeable mood;
- chloasma;
- skin rashes;
- acyclic vaginal discharge;
- migraine;
- amenorrhea after pill withdrawal;
- candidiasis;
- change in body weight in the direction of its increase;
- nausea.
When the above symptoms appear, the question of the advisability of further taking the drug is decided on an individual basis.
Severe side effects of "Novinet", which require immediate discontinuation of the drug:
- Sydenham's chorea (develops extremely rarely, the symptoms disappear after stopping the pills);
- exacerbation of Libman-Sachs disease (rare);
- acute blockage of veins / arteries by blood clots (rarely - myocardial infarction, DVT, PE, stroke;
- hypertension;
- porphyria;
- otosclerosis and, consequently, hearing loss.
Analogues of the drug "Novinet"
Full analogues for the active element:
- Mercilon.
- Regulon.
- Tri Mercy.
- Marvelon.
Price and holiday conditions
The average price of "Novinet", tablets 21 pcs. (Moscow), is 440 rubles. You can buy medicine in Minsk for 12.4 bel. rubles. The price of the drug in Ukraine is 160 hryvnia, in Kazakhstan - 1975 tenge. Released by prescription.
Store at 15-30°C. Keep away from children. Shelf life - 3 years.