Tablet "Silhouette": reviews of doctors, instructions for use. Contraceptive pills "Silhouette": reviews for endometriosis. Silhouette Applications for Endometriosis How to Take Silhouette First
![Tablet](https://i2.wp.com/syl.ru/misc/i/ai/312403/1761142.jpg)
To prevent unwanted pregnancy from occurring unexpectedly, contraceptive methods must be carefully considered. For these purposes, hormonal contraceptives are ideal. They have proven effectiveness. In addition to the main functions, these oral contraceptives have others. For example, against the background of their intake, the condition of the skin and hair improves, weight normalizes, and hormonal imbalance is eliminated.
In this article, we will consider the contraceptive pills "Silhouette". Feedback from patients and doctors will also be given.
The mechanism of action of the drug and its composition
The drug has a pronounced antiandrogenic effect due to the action of two main and several auxiliary substances that are part of its composition.
Below is the composition of the drug "Silhouette" (reviews confirm its high efficiency):
Dienogest;
ethinylestradiol;
Corn starch;
lactose monohydrate;
magnesium stearate.
Ethinylestradiol is a hormonal agent of the estrogen series (estrogen), dienogest also belongs to hormonal substances (progestane).
These components do the following:
They slow down peristalsis in the fallopian tubes, that is, muscle fibers do not contract so intensely, as a result, the egg cannot actively move through them;
Decreased sex drive;
Sleep problems.
The most common unpleasant phenomenon is the occurrence of pulling pain in the lower abdomen, as well as nausea and headaches. But for most women, they passed within a month and a half after taking the first pill.
The negative impact of smoking is not excluded. Therefore, in order not to aggravate the side effect of "Silhouette", smoking must be quit, better - long before taking the drug.
To the drug "Silhouette" instruction (reviews confirm this) indicates that there are certain features of taking combined oral contraceptives. First of all, they must be prescribed by a doctor. Self-administration is unacceptable, since uncontrolled intake of hormones can harm the body.
After the drug is purchased, it is necessary to carefully study the instructions for use. It states the following:
If a woman only plans to start taking this medication, then this should be done on the first day of menstruation.
If a woman has already taken another hormonal drug, then "Silhouette" can be drunk a day after the end of the course of the previous remedy.
It is necessary to drink a tablet at the same time every day. Drink a small amount of plain water. The dosage of one tablet should not be exceeded.
On each blister, arrows indicate the order of administration. It must be adhered to and in no case be violated.
If a woman had an abortion in the first trimester of pregnancy, then the contraceptive must be taken on the same day that the operation is performed.
In case of abortion or childbirth in the subsequent trimesters, the contraceptive must be used 28 calendar days after surgery or natural delivery.
No need to take breaks in taking hormonal contraceptives, this is not necessary. Thus, you can only harm your body by creating artificial hormonal surges.
In case of skipping the pill due to forgetfulness, it must be drunk immediately, as soon as the woman remembered it.
If there was vomiting a few hours after taking the drug, you need to take the pill again, because the previous one did not have time to digest.
This distinguishes contraceptive pills "Silhouette". Reviews about them are mostly positive.
Before starting the reception, you need not only a consultation with a specialist, but also a complete examination of the whole organism. This will help to identify existing pathologies that prevent the use of oral contraceptives. A woman may also be pregnant, which needs to be clarified in advance.
If you violate the procedure for taking Silhouette tablets, this can lead to a serious hormonal imbalance in the body.
Simultaneous reception with other means
Is the use of the drug "Silhouette" always allowed? The reviews confirm that the interaction of the drug with other hormonal agents is unacceptable. Also, some drugs during the period of treatment with the agent in question should not be taken. These include:
- Phenobarbital.
- Tetracycline.
- St. John's wort extract.
- Ampicillin.
- Carbamazepine.
- Ritonavir.
- "Ribafutin".
These drugs lead to bleeding from the genital tract, and the effect of contraception may be reduced.
Some medicines, the action of which is aimed at reducing the clearance of sex hormones, including those cannot be taken together with the "Silhouette".
special instructions
If any side effects occur while taking combined oral contraceptives, you should immediately see a gynecologist and inform him about it. Perhaps he will prescribe another drug that will provide the desired effect without a negative effect on the body.
Why does the condition of the skin and hair improve during the use of hormones? This question interests many. This is due to the decrease in sebum production. Hair becomes less oily as a result, and acne does not form on the skin. But you should not take the drug only for this. You should always remember about contraindications and side effects.
"Silhouette": reviews of doctors and patients
There are numerous reviews about these contraceptives. Doctors prescribe them not only for protection, but also for the treatment of various women's problems. Tablets are generally well tolerated, side effects are extremely rare. Patient reviews confirm this.
Many women like the condition of the skin against the background of taking "Silhouette", as well as the fact that the pain has stopped during menstruation. Some people have increased headaches, but, in general, the reviews are good.
In the modern world, a large number of different drugs are being developed on an ongoing basis to help maintain a normal lifestyle for any person. Of course, drugs are divided into several categories.
One of the popular categories of drugs is contraceptive drugs.
To be more precise, it may not necessarily be tablets, but also a drug produced in any other form. Undoubtedly, contraceptive drugs should be carefully selected taking into account all the characteristics of the patient.
It often happens that contraceptives cause quite a lot of damage to women's health during use.
Under no circumstances should this be allowed. Preparations of this purpose should not only preserve the health of a woman, but at the same time perform their intended function with high quality. For this, it is necessary to select the drug together with the doctor.
Oral contraceptive "Silhouette" is one of the well-known contraceptives.
What is Silhouette?
The drug is a contraceptive drug in tablet form, produced in a special white shell.
The basis of the composition are components such as:
- magnesium Ingredient,
- dienogest
- ethinylestradiol.
As part of these tablets, added as complementary and auxiliary components: magnesium stearate, corn starch, talc, and others.
As a rule, these components form an addition to the basis of any drugs that have a direct effect on women's health.
Pill Action Silhouette
Before you start taking pills, probably, anyone will be interested in the purpose and effect of the drug. These are the kinds of questions you need to ask before you start taking medications.
This is especially true of hormonal drugs, the use of which must be adjusted by a highly qualified specialist doctor.
The components that form the basis of the composition of the tablets "Silhouette" contribute to the stimulation of inhibited ovulation, as well as a change in the structuring of the endometrium and fallopian tubes.
In addition, this drug has such an effect as increasing the viscosity of cervical-type mucus, which, by the way, is important.
Indications for use
Undoubtedly, speaking about a particular drug, it is necessary first of all to familiarize yourself with what indications for use are established directly by the manufacturer.
This drug is used as an oral contraceptive.
In addition, quite a few patients choose this drug to get rid of acne, and in rare situations, a contraceptive is prescribed for endometriosis.
Application scheme
As you know, the Silhouette tablets are among the hormonal drugs and the use of these tablets is recommended to be observed in accordance with the instructions and recommendations of the doctor.
Probably, many are aware of the release of hormonal tablets in non-standard packages, which are divided into several parts, for the convenience of the patient.
Of course, it is extremely important to keep the schedule for taking these pills, as with many other hormonal drugs.
After all, the slightest overdose can have a strong impact on the health of any woman, which, of course, must be avoided.
Apply the drug according to the following scheme:
- Reception of a tablet is carried out 1 time at the same time. That is, the drug must be used daily at the set time, while drinking a tablet with a large volume of drinking water.
- Taking these pills is carried out for twenty-one days, and subsequently it is necessary to take a break for a week (for seven days). Then it is allowed to use the next package after the break.
- If the patient has not previously used or used such drugs, then it is necessary to start using "Silhouette" from the first day of the menstrual cycle.
- If the patient has replaced this drug with any other, then the use of "Silhouette" is recommended to start on the first day, after a break, or, it is permissible to start using the next day, after taking the final dose of another contraceptive.
The use of this drug is allowed after an abortion at any time, and after the postponed childbirth, it is allowed to take this drug only after 3-4 weeks and only with the consent of the doctor.
Missing a pill
It often happens that patients forget to take the next pill of a particular drug.
Unfortunately, it is very easy to forget to take a pill. In the daily bustle, many forget that the regime is above all, especially when it comes to hormonal-type drugs.
How to be in that case? It is very important to note that the omission of hormonal drugs, such as "Silhouette", which are among the hormonal drugs, can have a negative impact on health.
It is worth saying that the entire schedule for taking pills can go astray and be disrupted.
In fact, the price of skipping such a pill can be quite high, and first of all, unfortunately, for women's health.
Situations of skipping pills:
![](https://i2.wp.com/woman-centre.com/wp-content/uploads/2017/09/siluet-tabletki.jpg)
It is impossible to predict further development during the period of treatment with these tablets. If we talk about the primary week, then you can immediately drink a pill that is counted as a missed one.
Despite the fact that you have to take two tablets at the same time, you should take the missed tablet without fail.
- If the patient missed a pill, then within a week after the missed pill, it is necessary to protect yourself with condoms. This is primarily due to the fact that the drug may lose its effectiveness for some time and it is better not to hope for the full effect of this drug.
- If we talk about the second week of taking this drug, then you need to drink the pill that was missed as soon as possible. In this case, it is not recommended to apply and use any other barrier methods of contraception.
- If we are talking about the third week, then it is worth noting that the drug is not so effective, provided that the woman has not previously missed taking pills during the treatment process.
Can children take Silhouette?
Speaking of drugs like "Silhouette", it should be noted that the drug, first of all, should be prescribed by a highly qualified medical specialist.
No doctor will prescribe such a drug to a child who has not reached a period of transitional age.
Only if there is excessive acne formation, a teenage child may be prescribed therapy with the "Silhouette", but this is allowed at the age of 16 years and older.
Children under 16 years of age are prohibited from such a drug and it can only be prescribed according to individual doctor's prescriptions.
Admission during pregnancy and lactation
The process of pregnancy is quite an important period in the life of any woman.
If you look at the composition of the "Silhouette" tablets, it is immediately worth noting that during pregnancy it is forbidden to take this drug.
What to do in this case, if you managed to get pregnant during the period of using this drug?
In such cases, you should not only consult a doctor, but also immediately cancel the drug.
This is primarily due to the fact that there is not enough evidence to suggest that it is safe during childbearing and lactation.
Not only during pregnancy, but also during lactation, the drug "Silhouette" must be stopped.
Admission for impaired renal function
Kidney dysfunction- a very common occurrence. Of course, this problem is still important today. After all, quite a lot of patients have problems with the kidneys and liver.
In such cases, not only food and consumption of certain types of products are limited, but there are also restrictions on medicines.
Tablets directly contribute to a significant effect on the body, including the kidneys and liver.
In case of impaired renal function, you need to be observed by a doctor, as well as clarify information on whether it is possible to take a drug such as "Silhouette", if necessary.
Contraindications
Of course, any drug has a number of contraindications that you need to familiarize yourself with. You need to know that contraindications in the instructions are explained to the patient for a reason.
Due to the fact that the hormonal drug has a strong effect, it is necessary to inquire about what contraindications the manufacturer has established.
If the drug is prescribed by a doctor, it is also necessary to notify the presence of any diseases so that the doctor takes into account all the features and contraindications. In some cases, Silhouette should not be used.
Among the contraindications are diseases such as:
- deep vein thrombosis;
- vein thrombosis;
- thromboembolism of an organ such as arteries (pulmonary type);
- arterial thrombosis;
- thrombophlebitis;
Contraindications for patients with cardiac problems:
- angina;
- heart attack;
- cardiac ischemia;
- violations of the work and function of the valve apparatus;
For patients with other diseases:
- pancreatitis;
- jaundice;
- diabetes;
- liver disease
And also with individual intolerance to the components of the drug.
Side effects
Of course, in the process of taking any hormonal drug, depending on what purpose it has, side effects may occur.
According to reviews, any oral contraceptive in the complex begins to affect the woman's body.
Of all the most famous side effects, there are such as:
![](https://i1.wp.com/woman-centre.com/wp-content/uploads/2017/09/siluet-protivoz.jpg)
Overdose
The most important thing is to be interested in how much dosage is the norm. After all, the dosage must be observed throughout the entire time while taking such a drug as "Silhouette".
In case of non-observance of the required dose, the formation of negative consequences affecting the health of the woman is possible.
The drug is not classified as acutely toxic.
Subsequently, after an overdose, there may be such consequences as:
- vomit;
- nausea;
- open in the vagina;
- from the vagina.
There is no specific therapy to combat an overdose that has already occurred. It is only necessary to observe the dosage and not violate the schedule for taking the pills.
special instructions
It is worth noting that before any patient begins to take this contraceptive, it is necessary to prepare:
![](https://i0.wp.com/woman-centre.com/wp-content/uploads/2017/09/ukazania-vrachei.jpg)
Analogues
Of course, any medicine has an analogue, and "Silhouette" is no exception.
Analogues are the following drugs:
- Janine
- Belara;
- Evra;
- Lindinet 30.
Storage conditions
Surely many people know that the instructions prescribe separately information on how to store the drug. In fact, many patients cannot provide decent storage of drugs, as it is written in the instructions.
It is for this reason that the drug begins to lose all available active properties and functions. Why, often, people do not see the effect and the result?
Firstly, this is due to the fact that the drug is stored in the wrong place. Secondly, the drug must be stored at the required temperature. This is pretty important.
In case of non-compliance with elementary storage rules, the drug loses its properties and, of course, its effectiveness, for the reason that the drug is bought.
In accordance with the instructions, such contraceptives must be stored first of all, of course, out of the reach of children.
Not infrequently, when diagnosing a disease, gynecologists prescribe Silhouette, the reviews of patients with endometriosis are quite good. Women who come to the gynecologist once a year for prevention, such a disease as endometriosis, is definitely not familiar. However, it is quite common and has brought many women a lot of health problems. Is it possible to conceive with endometriosis? What threatens this disease, what drug is the best? What symptoms precede the disease and how can it be cured?
Brief description of the disease
As you already understood, endometriosis is a very serious and insidious disease, in which tissue can grow on any internal organs of a woman, similar in composition to the layer lining the uterus.
Usually these changes can be seen in the pelvic cavity, namely on the ovaries, bladder, fallopian tubes, skin, vagina and other places.
There is an opinion that this disease can develop into something worse, namely cancer. However, such a judgment is erroneous, since endometriosis does not have cellular atypia, but with all this, it tends to grow and damage healthy tissues. It should also be said that only women of predominantly reproductive age suffer from this disease.
Causes
- Critical days. Experts have found that there is a kind of ejection of blood along with endometrial cells into the abdominal cavity. After a while, they freely pass into closely spaced tissues.
- Downed hormonal background. With this diagnosis, there is almost always a strong LH surge.
- No matter how trite it sounds, but heredity plays an important role in this matter.
- Weak immunity. If a woman's immunity is normal, it simply destroys all endometrial cells that have left the uterine cavity. And if it is weak, then these cells grow freely anywhere.
- Metaplasia. There is a statement that cells that have left the uterine cavity tend to transform from one tissue to another.
How is adenomyosis treated?
Since this is a very serious ailment, therapeutic treatment is usually carried out conservatively or surgically. The method of treatment is chosen depending on the location of the ectopia, and its stage. It is important to know that the detection of this disease passes only through laparoscopy. After the operation, you will still need to undergo a course of treatment to prevent a recurrence. With this disease, most often doctors prescribe pills silhouette, janine and a number of other means.
Medications that are most often prescribed for this ailment:
- Contraceptive pills, or as they are also called - oral contraceptives, this is janine, as well as yarina.
- Danazol.
- Tablets byzan, utrozhestan, duphaston.
Each drug has a different effect on the female body, so now we will study them in more detail.
Drugs for the treatment of endometriosis
Silhouette medicine is more popular, but its analogues are no less effective. To compare indications and side effects, you will need an instruction.
General information about "Silhouette"
The drug is a new generation product, manufactured by Gedeon Richter. This is an analogue of "Janine", and the tablets have similar properties. I would like to note that the drug silhouette due to its low cost is more accessible to our citizens. Dienogest, a component of this drug, has a mineralocorticoid, glucocorticoid effect on the human body. Among other things, dienogest is a safe substance, so almost everyone can use the tablets, there are no prohibitions on its use. Also in this medication there is also a second component - ethinylestradiol, this radical provides excellent digestibility of the compounds, which gives the stability of the action of ethinylestradiol. Reviews about the silhouette can be found different, both positive and negative. The thing is that the drug can act differently for each person and this must always be taken into account.
Janine and Yarina with endometriosis
The exact cause of the appearance of endometriosis has not been established to this day, but experts say that hormonal disorders are to blame for the development of this process. The drug Janine, as well as Yarina are very effective in endometriosis and this is due to the mechanism of their action. In the second stage of the cycle after immediate ovulation, an increased preparation of the body for pregnancy was noted. Janine and Yarina do not allow the eggs to come out of the ovaries, they simply block them. Contraceptives primarily anesthetize, normalize the disturbed menstrual cycle, and eliminate symptoms. Contraceptive medications do not allow ovulation to occur, because the endometrium cannot grow much. Among other things, contraceptive medications normalize the menstrual cycle.
As mentioned above, the drugs Janine and Yarina are quite effective in endometriosis. The components of these medicines exhibit powerful activity in the human body, which makes it possible to use them in small doses.
There are several effective schemes for taking these medicines. But, despite this, only the doctor selects methods of treatment on an individual basis. In order for the treatment to be successful, these medicines should be taken for at least six months without a break. If the result is positive, then the attending physician, as a preventive measure, may recommend taking the medicine for another three months. Reviews of women confirm the positive effect of such therapy.
Duphaston and Utrozhestan
These drugs have in their composition the female hormone, in connection with which they are very effective in combating this disease.
Medicines reduce the production of estrogen, which in turn inhibits the growth of the endometrium.
Therapy lasts approximately seven months, and sometimes even more, so prepare yourself mentally and physically for a long road to recovery. Tablets must be taken following the directions for use. You can’t stop halfway and stop taking pills, it’s very dangerous and threatens to relapse!
Danazol and adenomyosis
If someone does not know, then dianasol is a hormone of synthetic origin, if a girl uses it, then her body will stop producing sex hormones, thereby the foci of adenomyosis will significantly decrease. For the best effect, dinazol is recommended to be taken for at least six months. There should be no problems with the application, the instruction is available in several languages.
This drug was previously widely used in other countries, but patient reviews have slightly changed the opinion of doctors. Women began to complain about side effects, namely:
- Pain in the chest;
- Swelling of the mammary glands;
- Jumps in blood pressure;
- Violation of the cycle;
- Hair loss;
- acne;
- Facial hair growth.
Other treatments
It is not always possible to cope with the disease with a therapeutic method; in severe form, the doctor may recommend surgery.
Operational treatment
The chronic type of adenomyosis responds well to conservative therapy.
Sometimes no medicines can help, and even such a drug as janine, and then surgical intervention is required. Here is a list of diagnoses that require urgent surgical intervention:
- ovarian cyst;
- The drug did not help;
- The presence of several diseases of the uterus at once;
- The risk of developing a tumor in the ovaries.
Laparoscopy is a surgical method that involves an operation using a laser. It is to them that the doctor cauterizes the foci of the disease, but, of course, here you still can’t do without drugs, the drug Zhanin is perfect in this case. First, the doctor prescribes to drink pills in a course, after which the operation is performed.
It should be noted that after surgery, women can count on the restoration of childbearing function, in addition, if the patient drinks a course of janine, dinazol, or yarin, she will feel relief during the menstrual cycle - discomfort will pass and pain will decrease.
ethnoscience
Folk remedies have been used as a therapy for this disease since ancient times. However, you should immediately understand that traditional medicine is not a substitute for surgery or drug therapy. It is very important, before you decide to use folk remedies, to visit your doctor and consult with him on this issue.
0.03 mg.
Lactose, corn starch, hypromellose, talc, magnesium stearate, potassium polacrilin, as excipients.
Release form
Coated tablets No. 21.
pharmachologic effect
Inhibition of ovulation, changes in the structure of the endometrium and an increase in the viscosity of the cervical secret under the action of active substances provide reliable contraception. Dienogest - derivative norethisterone at a dose of 1 mg inhibits ovulation. It does not have a significant mineralocorticoid and glucocorticoid effect.
Pharmacokinetics
Ethinylestradiol rapidly absorbed in the intestine, and the maximum concentration is determined after 1.5-4 hours. Bioavailability is 44%. Almost completely associated with albumin . The equilibrium concentration is reached in the 2nd half of the cycle. A significant part is metabolized in the liver.
Excretion of metabolites takes place in 2 stages: their concentration decreases after 1 hour and finally after 10-20 hours. Metabolites are excreted by the liver and kidneys.
dienoges t is also rapidly absorbed in the intestine and after 2.5 hours the maximum concentration is determined in the blood. Bioavailability reaches 96%. Equilibrium concentration is reached in 4 days.
Contacts albumin blood. It is metabolized by hydroxylation, metabolites are inactive and are very quickly removed from plasma. The half-life is 9 hours. Most of it is excreted by the kidneys.
Indications for use
Siluet is used for treatment and for the purpose of contraception.
Contraindications
The drug Silute is contraindicated in:
- hypersensitivity;
- and deep veins;
- liver disease and jaundice;
- severe arterial hypertension ;
- severe dyslipoproteinemia ;
- with vascular complications;
- uterine bleeding of unknown origin;
- breastfeeding.
Side effects
Common side effects that Siluet may cause:
- nausea, vomiting;
- pain in the mammary glands, their increase;
- backache;
- cramps of the calf muscles;
- increased appetite;
- menstrual bleeding;
- weight gain;
- decreased mood;
- venous thromboembolism .
Rare reactions:
- abdominal pain;
- anemia ;
- increased excitability;
- blurred vision, dry eyes;
- tinnitus, hearing impairment;
- and fungal infections;
- phlebeurysm;
- weakness;
- flu-like symptoms;
- arthralgia , muscle pain.
Silhouette, instructions for use (Method and dosage)
Tablets are taken orally, one daily, in the prescribed order for 21 days. Tablets from a new package are taken after a week break. During this time, withdrawal bleeding occurs.
If the drug is taken for the first time, then you need to start taking it on the 1st day of menstruation.
When switching from other combined drugs, they begin taking after the usual break.
After in the first trimester, they begin to take immediately. After childbirth - on the 21st day.
If a pill is missed and the missed time is less than 12 hours, there is no need to worry about a decrease in contraceptive protection. However, you need to quickly take the pill. Reception cannot be interrupted for more than 7 days.
The instruction contains complete information on how to drink the drug in other situations, how to delay withdrawal bleeding and in which cases additional contraceptive measures are needed.
Overdose
With strict observance of the instructions, Siluette does not cause an overdose.
Interaction
Breakthrough bleeding may occur when taken with hydantoin ,
Endometriosis is a serious disease, the treatment of which is carried out conservatively or surgically, depending on the location of endometrioid ectopia and the stage of neglect of the process. It is important to remember that verification of this diagnosis is possible only with the help of laparoscopic intervention. After surgical procedures, they also cannot do without long-term pharmacological support, which prevents relapses of the disease. The first-line drugs that are recommended by the international community of doctors for therapy in this pathology are combined oral contraceptives (COCs). Often used medicine "Silhouette" for endometriosis, as one of the most modern and safe means.
"Silhouette" provides degeneration, regression and further atrophy of endometriotic foci, regardless of their location
General information about the drug "Silhouette"
"Silhouette" is an effective medicine of a new generation, which belongs to the group of monophasic low-dose contraceptives. It is produced by the Romanian pharmaceutical company Gedeon Richter and is a structural analogue of COC called Janine, which has the same medicinal properties. Unlike the latter, "Silhouette" is more affordable for women in our region due to its affordable price.
The definition "Monophasic" means that the concentration of the two active substances remains constant in each tablet, regardless of the day of the menstrual cycle. "Low dose" means that the dosage of dienogest in it is higher than in the means of other related pharmacological subgroups ("microdose" drugs).
"Silhouette" is an effective medicine of a new generation, which belongs to the group of monophasic low-dose contraceptives
The components of the drug and their pharmacokinetics in the body
It consists of a progestogen derivative and an artificial estrogenic compound in the following quantities:
- dienogest (2 mg);
- ethinylestradiol (0.03 mg).
Dienogest is a unique substance, the so-called “hybrid” progestogen, which originates from compounds of 19-nortestosterone and progesterone. It exhibits a bright progestogenic effect and does not have an androgenic, glucocorticoid or mineralocorticoid effect on the body. In addition, the specificity of the chemical structure determines its safety during metabolic transformations in tissues - this makes it possible to use dienogest for therapy lasting several years. Its structure determines the unique complex pharmacodynamic properties that "Silhouette" possesses.
Ethinyl estradiol belongs to the estrogen family of chemical agents and has been widely used in gynecology over the past decades. The ethynyl radical provides almost 100% digestibility of the compound in the gastrointestinal tract when administered orally. It also slows down the conversion of substances by cellular enzymes into less active biological forms of female hormones and the further breakdown of these products. This is a guarantee of the duration and stability of the action of ethinylestradiol.
Endometriosis is a serious disease that can be treated conservatively or surgically.
Pharmacodynamics of "Silhouette": general contraceptive and specific therapeutic effect
How the combined oral contraceptive "Silhouette" affects the hypothalamic-pituitary-ovarian axis and reliably prevents conception. This drug solves this problem in a complex:
- inhibits ovulation and folliculogenesis in the ovaries;
- changes the structure of the endometrium in the uterine cavity in this way and due to this makes it impossible for the embryo to implant in it;
- reduces the intensity of contractions of muscle fibers in the fallopian tubes, as a result of which their peristalsis slows down and obstacles are created for the movement of the egg if ovulation does take place;
- changes the properties of mucus in the cervical canal, making it thicker and more viscous, which negatively affects the movement of spermatozoa through the female genital tract.
The therapeutic effect on endometriosis, which the drug has, is based on the medicinal properties of the pharmacological group to which it belongs. Let's consider its main pharmacodynamic effects and trace the ways of its influence on the female body.
"Silhouette" provides degeneration, regression and further atrophy of endometrioid foci, regardless of their location. By reducing the intensity of estrogen synthesis and suppressing ovulation, it blocks the proliferative cyclic changes that the endometrium is subject to in and outside the uterine cavity. Dienogest in its composition eliminates local hyperestrogenism, affecting the mechanisms of intracellular communication. Due to this, the stroma of ectopic formations is differentiated and histological changes can be observed in it, similar to those that occur during pregnancy. Therefore, this condition is called “pseudodecidualization”. The epithelium is also transformed and acquires secretory features, significantly slowing down its growth in the future. This is how the bright anti-proliferative effect of “Silhouette” manifests itself.
How the combined oral contraceptive "Silhouette" affects the hypothalamic-pituitary-ovarian axis and reliably prevents conception
The second important property that this drug has is anti-inflammatory. It stops the local inflammatory response, as it inhibits the prostaglandin cascade and selectively blocks the formation of prostaglandins of the PG E2 type, as well as estrogen-like substances.
"Silhouette" significantly reduces the activity of such enzymes as cyclooxygenase-2, prostaglandin synthetase in ectopic epithelial cells. Patients get rid of intense pain in the pelvic area, which often becomes chronic.
There is a positive dynamics of the disease, the signs of dysmenorrhea and polymenorrhea disappear (heavy menstrual bleeding, which is accompanied by painful attacks), the severity of dyspareunia (pain during intercourse) decreases.
This drug accelerates and intensifies the local processes of the breakdown of female hormones to low and inactive components (the conversion of estradiol to estrone), which is another mechanism for normalizing the local estrogen background. The drug acts on a natural intracellular catalyst called 17-beta-hydroxysteroid dehydrogenase of the second type, which is responsible for the aromatization and degradation of these substances.
"Silhouette" inhibits angiogenesis, that is, it prevents the formation of new blood vessels around the focus of endometriosis, as it reduces the level of endothelial vascular growth factor in the blood. The production of other growth factors is stopped, and the immune response is also stimulated due to a decrease in the concentration of tumor necrosis factor-alpha (TNF-alpha). The amount of the midkine factor in follicular and peritoneal fluids, which plays a major role in the complex mechanism of endometriosis, is sharply reduced. The drug stops the implantation of endometrial cells outside the uterus, and also inhibits the metaplasia of the peritoneal mesothelium into the endometrial tissue.
Tablets "Silhouette" have an antianemic effect, normalize the exchange of Fe ions in the body and prevent the progression of iron deficiency anemia. Such an impact is due to the elimination of signs of dys- and polymenorrhea.
"Silhouette" inhibits angiogenesis, that is, it prevents the formation of new blood vessels around the focus of endometriosis
Japanese researchers found that dienogest, which is part of the drug, prevents malignancy (malignant degeneration) of ectopic foci, that is, it protects women who use it from cancer, significantly reducing the risk of their occurrence.
"Silhouette": features of endometriosis therapy
"Silhouette" is used for endometriosis in such cases:
- empirical therapy in patients with newly diagnosed endometriosis, especially if the process was diagnosed at an early stage;
- preoperative preparation of patients with more severe forms of the disease;
- postoperative pharmacotherapy in women to prevent recurrence of pathology.
Depending on the woman's fertility plans, that is, based on whether she plans to become pregnant in the near future, the gynecologist must select the appropriate dosage of the drug and explain in what way the pills should be taken.
When making a diagnosis of endometriosis, you need to take the issue of childbearing very seriously, since pregnancy has a positive effect on the patient's health - hormonal changes that occur during this period in the body contribute to the extinction of inflammatory processes and atrophy of endometrioid foci.
A consistently low concentration of estrogen in the blood, which occurs if you regularly take Silhouette tablets, also stimulates the reverse development and degradation of ectopic formations.
Tablets "Silhouette" have an anti-anemic effect, normalize the exchange of Fe ions in the body and prevent the progression of iron deficiency anemia
If the patient together with her partner wants to conceive a child or endometriosis was detected at an early stage, the drug is prescribed according to the standard “cyclic” scheme, which is often called the classic one: “21 + 7”. This means that a woman drinks the medicine at the dosage indicated by the specialist for three weeks, and then takes a break for a week. On the third or fourth day of the pause, she has menstrual-like bleeding. Usually in this case, the doctor prescribes pills for a period of three months to six months, based on the severity of the patient's condition.
He develops a further treatment strategy, taking into account the results of laboratory tests (blood chemistry, thrombin protein level and activity, ultrasound of the abdominal cavity and small pelvis), which a woman must undergo no later than 3 months after the start of therapy.
If the patient does not strive to become a mother as soon as possible, and also if it is necessary to prevent the recurrence of endometriosis after laparoscopic intervention, the tablets are recommended to be used according to the “prolonged” scheme: “42 + 7”, “63 + 7”, “84 + 7”. The drug is used for 6, 9 or 12 weeks, respectively, and then stopped for 7 days, causing a menstrual-like reaction. In this mode, the tool is used for several years.
The gynecologist must select the appropriate dosage of the drug and explain according to which scheme the tablets should be taken.
The doctor should warn the woman that the pills should be taken every day without interruptions and omissions, otherwise there may be a violation of the manifestation of general contraceptive and specific therapeutic effects, the development of unplanned bleeding of varying intensity and other negative consequences.
In the treatment of endometriosis, it is most favorable to start therapy with Silhouette on the first day of the menstrual cycle (the first day of natural menstrual hemorrhage). If the patient begins to drink pills within two to five days from the onset of menstruation, then the gynecologist is obliged to focus her attention on the fact that in the first week of admission it is necessary to additionally use barrier contraception.
What adverse reactions can occur when taking "Silhouette"?
Sometimes pharmacotherapy for endometriosis can cause negative reactions and have an undesirable effect.
All COCs with regular use cause an increase in the level of blood coagulation and the risk of thrombosis. This trend is especially pronounced in women who smoke. Therefore, if the gynecologist gave you a prescription for which you need to purchase Silhouette tablets at the pharmacy, you must quit smoking as soon as possible in order to maintain health and avoid deadly complications.
To stay healthy and avoid life-threatening complications, you need to stop smoking as soon as possible.
Patients suffering from blood clotting disorders, obesity, varicose veins of the lower extremities, uncontrolled arterial hypertension of any origin are also at increased risk for this type of side effects.
If preventive measures were not taken in time, there is a possibility of developing various thromboembolic complications:
- ischemic stroke of the brain;
- myocardial infarction or other organs (spleen, kidney, etc.);
- thromboembolism of the pulmonary artery;
- thrombophlebitis of deep and superficial veins of the upper or lower extremities;
Tablets "Silhouette" also affect the central nervous system. Sometimes they cause the following pathological phenomena:
- attacks of migraine-like headache;
- excessive excitation of the nervous system;
- dizziness.
- hearing impairment and distortion of auditory perception.
Contact lens wearers may also have problems, as one of the side effects of this medication is intolerance to these devices. Moreover, among the negative effects that concern the eyes are possible:
- deterioration in visual acuity;
- dryness and inflammation of the conjunctiva.
The psyche of patients may undergo such changes:
![](https://i2.wp.com/vrachlady.ru/wp-content/uploads/2015/10/zhenshhina-lezhit-v-posteli.jpg)
The organs of the gastrointestinal tract are also vulnerable. They are threatened with:
- phenomena of upper and lower dyspepsia (nausea, vomiting, constipation, flatulence);
- gastritis;
- cholecystitis and cholelithiasis (with the development of cholestatic jaundice);
- enteritis phenomena.
The reproductive system, on which the drug has its effect, may suffer as follows:
- acyclic bleeding of varying intensity or spotting from the vagina;
- soreness of the mammary glands and discharge from them, a change in their internal structure.
Which of the patients "Silhouette" is contraindicated?
The use of this drug in some patients can lead to unpredictable consequences. For women, there are such contraindications:
- thromboembolic diseases that are observed now or are present in history;
- hormone-dependent malignant tumors of the reproductive organs and mammary glands;
- jaundice of any etiology, as well as severe liver damage and its tumors;
- significant dyslipoproteinemia and coagulation disorders;
- migraine;
- epilepsy;
- uncontrolled essential hypertension;
- smoking over the age of 35.
How does Silhouette interact with other medicines?
The simultaneous use of this drug with such drugs that induce (activate) enzymes of microsomal oxidation in the liver can lead to a decrease in contraceptive and therapeutic effects:
- barbiturates;
- rifampicin;
- carbamazepine;
- griseofulvin, etc.
“Silhouette” is an effective and modern drug that, with endometriosis, is guaranteed to alleviate the condition of a woman and contribute to a speedy recovery.